Nacetylcysteine after traumatic brain injury on ICAM1 and the expression of NFB.doc

 PAGE \* MERGEFORMAT 14 Nacetylcysteine after traumatic brain injury on ICAM1 and the expression of NFB [Abstract] Objective To observe the N acetyl cysteine #8203;#8203;(NAC after traumatic brain injury on intercellular adhesion molecule 1 (ICAM 1 and nuclear factor B (NF B) expression to investigate the neuroprotective mechanism. Methods 90 Wistar rats were randomly divided into sham operation group (n = 6), TBI group (n = 42) and traumatic brain injury NAC treatment group (n = 42). freefall technique in rats with traumatic brain injury model, application Immunohistochemical detection of NF B and the expression of ICAM 1. Results Compared with sham group, the brain injury group NF B and ICAM 1 expression was increased, NAC can reduce the expression of NF B and ICAM 1, reduce the inflammatory response. Conclusion NAC could inhibit the NF B and ICAM 1 expression, reduce inflammation, play a role in brain protection. [Keywords:] brain injury of nuclear factor B N acetylcysteine #8203;#8203;intercellular adhesion molecule 1 Abstract: Objective To explore the effect of NAC on NF B and ICAM 1 expression after traumatic brain injury (TBI) in rats, and discuss the mechanisms of neuro protection by NAC.Methods Ninety adult male Wistar rats were randomly divided into sham group (n = 6), TBI group (n = 42) and NAC group (n = 42). The experimental TBI model was established by Feeney’s method.Samples were obtained after injury for inspecting the expression of ICAM 1 and NF B proteins by immunochemical method. Results Compared with the sham group, the expression levels of ICAM 1 and NF B were significantly increased after traumatic brain injury, and NAC significantly decreased the expression of ICAM 1 and NF B.Conclusion Expression of NF B and ICAM 1 decreased by NAC might be one of the mechanisms in regulating ICAM 1, NF B level and inhibiting inflammation in cortex and exerting protective function to neurons. Keywords:: brain injury; N acetylcysteine #8203;#8