Naloxone and compound Danshen treatment of neonatal hypoxic ischemic encephalopathy in 120 cases.doc

 PAGE \* MERGEFORMAT 5 Naloxone and compound Danshen treatment of neonatal hypoxic ischemic encephalopathy in 120 cases [Keywords:] Naloxone Danshen neonatal hypoxic ischemic encephalopathy Neonatal hypoxic ischemic encephalopathy (HIE after perinatal asphyxia is a serious complication of the neonatal period the most harmful common, often caused by neonatal death and neurological developmental disorders, nervous system, leading to injury of children the main reason for disability, serious harm to life and health of the newborn. our hospital in February 1999 ~ December 2006 and naloxone with Danshen treatment of the disease, has made a significant effect, are as follows. 1 Materials and Methods 1.1 General information on 244 children were hospitalized, according to the clinical diagnosis established by the Conference of Jinan and indexing based on the standard [1], randomly divided into two groups, the treatment group of 120 patients, 76 males, female 44 cases, gestational age lt;37 Week of 64 cases, 50 cases of 37 to 41 weeks,gt; 41 weeks in 6 cases, 68 patients with mild, moderate 36 cases, severe in 16 patients. the control group 124 patients, two groups of age, gender, body weight difference was not statistically significant (P gt; 0.05, the condition with similar clinical manifestations, diagnostic criteria are in line. 1.2 The treatment groups were given oxygen, incubator warm, energy mixture, reduce intracranial pressure, just shocked, improve microcirculation and other comprehensive treatment measures. The treatment group received compound Danshen injection 2 ~ 3 ml / (kg · d, adding 10% glucose injection 30 ~ 50 ml intravenous infusion, day 1, once every 14 days as a course of treatment, while the early admission of naloxone used in conjunction, by 0.1 mg / (kg · d calculation, use 3 to 4 days According to the degree of respiratory depression in children, first taken within 0.2 mg intravenously at the dropper, and in 60 ~ 90 min,