Mycoplasma hyorhinis P40 protein expression in renal cell carcinoma and its significance.doc

 PAGE \* MERGEFORMAT 14 Mycoplasma hyorhinis P40 protein expression in renal cell carcinoma and its significance Of: Cao, Li Jianping, Cheng Wei, CHEN Qi [Abstract] Objective To detect Mycoplasma hyorhinis P40 protein expression in renal cell carcinoma, of mycoplasma infection and the relationship between renal cell carcinoma. Methods hospital paraffin-embedded specimens of 95 cases of renal cell carcinoma to the normal kidney from renal cell carcinoma tissues 60 cases as control, were detected by immunohistochemistry in renal tissue Mycoplasma hyorhinis protein P40. Results in Renal Cell Mycoplasma hyorhinis P40 protein expression rate was 64.2% (61/95), adjacent normal renal tissue, the positive expression rate was 21.7% (13/60), the difference was significant statistically significant (P lt;0.001). Conclusions The occurrence of renal cell carcinoma with mycoplasma infection has some relevance, mycoplasma infection may be renal cell biology factor. [Keywords:] mycoplasma infection kidney ABSTRACT: Objective To investigate the association between mycoplasma infection and pathogenesis of renal cell carcinoma (RCC). Methods There were 95 samples of archived embedded tissues of RCC and 60 samples of archived embedded normal renal tissues around the tumor for comparison. We detected mycoplasma hyorhinis P40 expression in archived embedded renal tissues by immunohistochemistry (IHC) with mycoplasma hyorhinis monoclonal antibody (MAb) PD4. Results Mycoplasma hyorhinis P40 was present in 64.2% (61/95 cases) of RCC and in 21.7% (13/60 cases) of the paratumor normal renal tissues in controls. The mycoplasma hyorhinis P40 expression ratio in RCC was significantly higher than that in the normal renal tissue, around the tumor (P lt;0.001). Conclusion There was a correlation between mycoplasma infection and pathogenesis of RCC. Mycoplasma infection could be a biological factor in the oncogenesis of RCC. KEY WORDS: mycoplasma; infection; renal cell carcinoma