Mycophenolate flavonoids in rats Pharmacokinetics.doc

 PAGE \* MERGEFORMAT 8 Mycophenolate flavonoids in rats Pharmacokinetics Of: Wang Guihong, Liu Dan, Wu Jie, Bing rainbow, Zhang Guobin, Zheng Guohua [Abstract] Objective To study the mold of tea flavonoids in vivo pharmacokinetics. Methods Ampelopsin as the index, high performance liquid chromatography (HPLC) determination of serum after administration of the concentration of Ampelopsin. Results Rats were 0.5 h, can be detected in serum ampelopsin, mycophenolate flavonoids in rats showed a one-compartment model distribution, and drugs in high, medium and low doses of drug concentration in comparison. Conclusion HPLC Method for determination of total flavonoids Meicha rats plasma concentration of total flavonoids absorbed rapidly in rats, the concentration of the drug had no significant effect in vivo metabolic behavior. [Keywords:] mold flavonoids, Ampelopsin, pharmacokinetics, rats, high performance liquid chromatography Meicha Department Vitaceae Ampelopsis Ampelopsis plants large leaf Ampelopsis.megalophylla Diels et. Gilg processed from branches, the main active ingredient mycophenolate flavonoids, clinically used blood pressure, blood fat [1]. For Flavonoids Meicha pharmacokinetic study reported that less mold in order to further understand the mechanism of flavonoids in the blood pressure, the experiment at mycophenolate flavonoids in vivo pharmacokinetics in rats were studied. 1 Materials and equipment 1.1 Drugs and reagents Mycophenolate flavonoids, Ampelopsin standard (self, acetonitrile (HPLC grade), with mycophenolate flavonoids 4% CMC-Na solution, the concentration required to dissolve into heated. 1.2 Animals SD rats weighing 200 ~ 250 g, male and female, from Tongji Medical College, Huazhong University of Science Faculty of experimental animals to provide, license number: SCXY (E 2004-00070. Room temperature 18 ~ 20 , and fed during the experiment provided by the Centre solid feed, free access to water. 1.3 Instrument