Naloxone treatment of severe neonatal hypoxic ischemic encephalopathy effect.doc

 PAGE \* MERGEFORMAT 8 Naloxone treatment of severe neonatal hypoxic ischemic encephalopathy effect [Abstract] Objective To observe the naloxone treatment of severe neonatal hypoxic ischemic encephalopathy. Methods of clinical diagnosis of 68 cases of severe neonatal hypoxic ischemic encephalopathy 34 cases were randomly divided into treatment group and control group 34 patients in the control group was treated with combined therapy, the treatment group on the basis of comprehensive treatment, addition of naloxone 0.4 mg / d, adding 30 ml 10% glucose intravenous drip to maintain 4 ~ 6 h, 5 to 7 days treatment . Results In both groups in the central respiratory failure, gastrointestinal disorders, poor circulation, kidney failure, consciousness recovery time, reflecting differences in recovery were significant (P lt;0.01). Conclusions Neonatal naloxone treatment of moderate to severe shortage Oxygen significant ischemic encephalopathy, can promote clinical improvement, reverse the brain damage, and promote functional recovery of damaged nerves, blocking the pathogenesis of secondary brain injury in the process. [Keywords:] Naloxone; neonatal hypoxic ischemic encephalopathy Neonatal hypoxic ischemic encephalopathy (HIE) is a variety of perinatal asphyxia caused by partial or complete lack of oxygen, cerebral blood flow reduction or suspension, and result in fetal or neonatal brain injury [1]. Is still threat to life and health of newborns serious diseases, in addition to resuscitation outside the effective control methods is no generally accepted, although the obstetric and neonatal care technology development, but the incidence of HIE was still high, mortality and survival were the incidence of neurological sequelae were high [2]. Therefore, HIE norms for early diagnosis and timely treatment, more and more aroused the attention of all pediatric practitioners. our department from January 2008 to January 2009 were treated with moderate to severe hypoxic i