Natural-type CD4 CD25 Treg cells in the thymus differentiation and development.docVIP

 PAGE \* MERGEFORMAT 29 Natural-type CD4 CD25 Treg cells in the thymus differentiation and development Keywords: CD4 + T lymphocytes;, T lymphocytes;, DNA-binding proteins;, transcription factor;, thymus;, immune tolerance;, cell differentiation;, review (literature type) CD4-positive T lymphocytes;, T lymphocytes;, DNA-binding proteins;, transcription factor;, thymus;, immune tolerance;, cell differentiation;, review (literature type) Keywords:: CD4-positive T lymphocytes; T lymphocytes; DNA-binding proteins; transcription factor; thymus; immune tolerance; cell differentiation; synthesis (literature type) Regulatory T cells (Treg cells) in vivo in recent years to determine the existence of a class of T cell subsets, according to the different sources of Treg cells can be divided into natural-type and inducible two kinds of [1]. Natural-type Treg cells (CD4 CD25 Treg cells) is a natural differentiation of thymocytes from one of the major development of Treg cell subsets; of inducible Treg cells (Th3 or Tr1 cells) is a peripheral mature CD4 CD25-T cells are specific antigen stimulation and cytokine induced into cells with functional characteristics of Treg cell subsets. The current study shows that fork head / winged helix transcription factor (Foxp3) is the Treg cell specific markers, in the regulation of their development and function play a very important role. However, there is the generation of Treg cells and differentiation of growth so far poorly understood, and there are differences. I mainly from the natural non-Treg cell generation and differentiation and development have done a review. A natural-type CD4 CD25 Treg cells produce CD4 CD25 Treg cells, arising primarily from the thymus. OK neonatal thymectomy in mice and human thymic hypoplasia (DiGeorge syndrome) can lead to impaired Treg cell development and lead to the occurrence of organ-specific autoimmune diseases [23]. Adoptive transfer of CD25 T cells, removal of