Near infrared spectroscopy in rat glioma in the application of radiofrequency hyperthermia.doc

 PAGE \* MERGEFORMAT 15 Near infrared spectroscopy in rat glioma in the application of radiofrequency hyperthermia Of: Cheng-Shyong Chang, Yu Yang, Yang Tianming, Qian Yu [Abstract] Objective: To study the near-infrared spectroscopy (NIRS) technology used in stereotactic surgery radiofrequency hyperthermia glioma real-time monitoring and efficacy evaluation of the feasibility of, and observe the process, changes of NIRS parameters. Methods: In rat right caudate nucleus of brain C6 glioma cells were injected into rat glioma model of normal and tumor-bearing rats were targeting radio frequency heating, were observed and recorded brain tissue and tumor tissue RF heating, especially when the target of the NIRS parameters is the reduced scattering coefficient of variation. Results: (1) the caudate nucleus of 60 rats after injection of C6 cells reduced activities of 55 occurred, water diet gradually as the reduction in body weight after 10 d reduced by magnetic resonance imaging proved successful model, (2) right caudate nucleus of RF heating, the temperature points in the characteristic changes occurred under the NIRS curves. Conclusion: NIRS in vivo real-time monitoring and assessment of the reign of glioma efficacy of radiofrequency hyperthermia in rats is scientific and feasible, which reduced scattering coefficient is the effect of a good assessment and monitoring indicators. [Keywords:] near-infrared spectroscopy, reduced scattering coefficient, three-dimensional positioning technology, glioma, hyperthermia; rat Glioma surgical excision, the tumor showed invasive growth, with no clear boundaries in brain tissue is difficult to complete resection, postoperative radiation therapy, chemotherapy, immunotherapy is very necessary, but various treatments are difficult to achieve Objective cure [1]. tumor hyperthermia treatment of cancer is heating method, which uses a variety of physical energy deposited in body tissues resulting thermal effects, and to ma