Neo-adjuvant chemotherapy in the treatment of NP programs and FEC compared 122 patients with breast cancer.doc

 PAGE \* MERGEFORMAT 4 Neo-adjuvant chemotherapy in the treatment of NP programs and FEC compared 122 patients with breast cancer [Abstract] [Objective] To compare the program with the FEC observe the NP program neoadjuvant breast cancer chemotherapy efficacy and toxicity. [Methods] 122 patients with stage Ⅱ , Ⅲ randomized breast cancer patients. NP Program Group: NVB 25mg/m2 the first 1,8 days, DDP 30mg/m2 1 to 3 days, FEC program group :5-Fu 500mg/m2 the first 1,8 days, EPI 25mg/m2 the first 1,2 days, CTX 500mg/m2 the first 1,8 days. Every 3 weeks for a course of treatment, after the completion of two courses, the two groups of patients were observed in primary tumor size and regional lymph nodes to defuse the situation and to observe toxicity. [Results] NP group, the total efficiency of 70.3%, including CR 6 Li, PR 39 Li, NC 19 Li. FEC group, the total efficiency of 51.7%, CR 2 Li, PR 28 Li, NC 28 cases, there was no progress in those two groups. Phase Ⅱ Phase Ⅲ higher efficacy. NP group leukopenia and gastrointestinal reactions than FEC group, two groups of hair loss at a similar level. [Conclusion] NP and the FEC program neoadjuvant chemotherapy in the treatment of stage Ⅱ , Ⅲ breast cancer are effective, toxicity groups were tolerable, NP group efficacy and toxicity is higher than the FEC group. [Keywords:] breast cancer neoadjuvant chemotherapy NP program FEC program Neo-adjuvant chemotherapy of breast cancer as an effective treatment measures, more and more people’s extensive attention. We are from January 2003 to December 2005 used to NVB (navelbine, NVB) plus cisplatin (cisplatin, DDP), or fluorouracil (5-fluorouracil ,5-Fu), epirubicin (epirubicin, EPI ) plus cyclophosphamide (cyclophosphamide, CTX) program of neo-adjuvant chemotherapy for stage Ⅱ , Ⅲ 122 patients with breast cancer to observe the efficacy and toxicity. 1 Materials and methods 1.1 The object of study 122 cases were characterized by pathological examination or fine needle a