Neonatal jaundice on the blood and urine β2-microglobulin and its clinical significance.doc

 PAGE \* MERGEFORMAT 7 Neonatal jaundice on the blood and urine β2-microglobulin and its clinical significance [Keywords:] neonatal jaundice, β2 microglobulin Neonatal jaundice is a common clinical phenomenon, caused by elevated bilirubin in the blood. In addition to traditional medicine that neonatal jaundice serum bilirubin concentration, in general, does not cause body damage, but in recent years, it was found that high bilirubin organ damage when the newborn factors are objective, and may cause permanent damage to advocate aggressive treatment [1]. Some studies suggest neonatal jaundice presence of renal dysfunction, the paper patients were detected in 80 cases of neonatal jaundice child of blood and urine β2-microglobulin levels of neonatal jaundice in the early diagnosis of renal dysfunction. 1 Data and methods 1.1 General Research group (80 cases selected cases in March 2007 ~ February 2008 hospitalized patients, patients meet diagnostic criteria [2]. 37 to 42 weeks gestational age, birth weight 2 500 ~ 4 000 g. 45 males and 35 female, aged 2 to 33 days. caesarean section in 43 cases, 37 cases of flat production. no distress, no longer second stage of labor, Apgar score 9 to 10 minutes, blood bilirubin was 91.9 ~ 460.7 μmol / L. control group (30 patients: selected from the same period in the normal birth in hospital newborn obstetrics. two groups are Han people in East China, no genetic diseases, feeding, gestational age, age, gender, weight to match. 1.2 Methods All subjects were fasted 4 h after the morning in the femoral vein collected 2 ml, the urine sample collection: a one-time collection bags of urine specimens from 5 ml. Specimens of 2 ℃ ~ 8 ℃ preservation inspection. By hand than with a scattering Turbidimetric Determination of serum and urine β2-microglobulin values. serum bilirubin concentration in neonatal jaundice 91.9 ~ 171 μmol / L, 171 ~ 257 μmol / L, 257 ~ 342 μmol / L,gt; 342 μmol / L to group . 1.3 Main apparatus and