Neural stem cell research and application of new advances.doc

 PAGE \* MERGEFORMAT 23 Neural stem cell research and application of new advances [Keywords:] neural stem cell research In 1992, Reynolds [1] for the first time successfully isolated from the striatum of adult mouse neural stem cells (neuralstemcell, NSC), then ‘neural stem cells’ have been formally introduced the concept of neurological Science fields of study. Can be summarized as having to differentiate into neurons, astrocytes and oligodendrocytes in the capacity of glial cells can Self-renewal and is sufficient to provide a large number of cells in brain tissue cells. A lot of the literature also referred to the neural progenitor cells and nerve Precursor cells, at present the view that neural progenitor cells, refers to the NSC is more explicit than the direction of development of cells, while the neural Precursor cells is the proliferation of cells in the early developmental stage may refer to NSC and neural progenitor cells: in comparison with the NSC , The two split the proliferation of weak and strong differentiation is limited proliferating cells, but the three are NSC Category. 1.NSC origin, there are location and biological characteristics of The development of the central nervous system originated in the neural groove, neural crest, neural tube; study found that, NSC God The wall of the proliferation of new cells migrate to the radial fibers of the brain a specific location; mainly in ependymal zone, In the germinal zone into the brain is also widely distributed outside the region, namely, high plasticity of neural precursor cells. The biological characteristics of NSC are found as follows: (1) has a self-renewing capacity; (2) with multi-directional Differentiation potential, differentiate into neurons, astrocytes and oligodendrocytes; (3) in a highly undifferentiated State; (4) with the proliferation and differentiation of life-long ability to damage the local environment where the signal change may be stimulated