Neuroleptic malignant syndrome caused by the diagnosis and treatment of.doc

 PAGE \* MERGEFORMAT 6 Neuroleptic malignant syndrome caused by the diagnosis and treatment of Neuroleptic malignant syndrome induced by (NEUROLEPTIC MALIGNANT SYNDROME, NMS) is a result of taking antipsychotic drugs caused a fatal syndrome. Clinical features appear for the first disturbance of consciousness, extrapyramidal symptoms, after high fever, salivation, sweating, tachycardia and other nerve disorders hypothalamic syndrome Hou groups of plants. In our hospital from 1995 to 2005 caused by antipsychotic treatment of patients with acute and 70 cases admitted to hospital diagnosed 11 cases of NMS. Now the diagnosis and treatment of this disease are summarized as follows: A clinical data 1.1 General Information 11 patients, including 8 males and 3 females, aged 17-40 years old. Past history of eight cases of schizophrenia, according to normal therapeutic doses under the supervision of specialist doctors or family medicine: taking chlorpromazine in 3 cases, the longest time a year, the shortest time of 3 days; taking chlorpromazine fluoride faction PI alcohol in 1 case, time is 15 days; taking clozapine in two cases, the time 2 months; taking lithium carbonate in 2 cases, the time for 2 years. Three cases of patients with no history of mental illness: one cases of neurasthenia from the post-taking perphenazine 1 week; two cases of attempted suicide as a result of family disputes, 100 were one-time oral administration of amitriptyline, chlorpromazine 50 2 hours and admission. 1.2 clinical manifestations of 4 cases from outside the hospital diagnosed as having encephalitis, toxic shock, acute renal failure in turn, 7 cases with coma of unknown origin, acute poisoning accept this. 11 cases appeared as shallow coma, muscle rigidity, muscle tremors, convulsions, sweating, salivation, fever, tachycardia, shortness of breath, of which 8 cases were low blood pressure condition. Laboratory examination: WBC were 15-20 * 109 / L, urine protein; SGPT, SGOT, BUN incr