Neutrophil activation in myocardial ischemia-reperfusion injury.doc

 PAGE \* MERGEFORMAT 16 Neutrophil activation in myocardial ischemia-reperfusion injury [Abstract] Because myocardial ischemia-reperfusion injury (ischemic / reperfusion injury, I / R) mechanism of the complex, making it more difficult clinical and prevention are often faced with the problem. In many of its occurrence and development mechanism of the neutral granulocytes (PMN) activation, myocardial infiltration and degranulation may be the final link or path. a large number of studies have shown that neutrophils through the release of cytotoxic substances such as proteolytic enzymes, oxygen free radicals, lipid media, a variety of inflammatory medium and block small blood vessels such as ischemia-reperfusion induced myocardial injury. know the cellular mechanisms undoubtedly contribute to research and find the prevention of myocardial ischemia-reperfusion injury of the method. In this paper, in recent years, neutrophil activation in myocardial ischemia reperfusion injury and its prevention mechanisms of research are summarized below. [Keywords:] neutrophil myocardial ischemia-reperfusion injury in myocardial protection Studies have shown that myocardial ischemia and neutrophil activation during reperfusion, myocardial infiltration and degranulation of myocardial ischemia-reperfusion injury is an important cellular mechanisms. Therefore, the research and development of inhibition of neutrophil activation methods and measures, should help in myocardial protection. 1, neutrophil activation and myocardial ischemia-reperfusion injury in rats 1.1 The activation of neutrophils initial factor under normal circumstances, circulating in a non-activated PMN must chemokines and effect of activating agent was only activated, or damaged tissue and then to the inflammatory infiltration and degranulation in , causing tissue damage. these chemokines include: IL 8, IL 6, TNF a, c3a, c5a, oxygen free radicals [1]. 1.2 neutrophil infiltration (1) ischemic area a