Niaoduqing Enema of the rat model of chronic renal failure.doc

 PAGE \* MERGEFORMAT 8 Niaoduqing Enema of the rat model of chronic renal failure Of: Weixiu De Lili Jing Wang Deyou [Abstract] Objective To observe Niaoduqing enema on experimental chronic renal failure in rats. Adenine gavage method of approach to the establishment of chronic renal failure rat model, the establishment of the normal group (or sham operation group), model group, Niaoduqing enema high dose group (4.52 g / ml), low dose (2.26 g / ml) and the positive control group Shenshuaikang enema, enema administration, medication 2 w or 12 w. aging rats before treatment and after different periods of 24 h urine volume, urinary protein, specific gravity, urine creatinine, after treatment of blood Cr, BUN, P, K +, Na +, Ca2 +, RBC, HGB, HCT. the results of model rats in each group of adenine significant weight, poor nutritional status, serum Cr, BUN increased, significant changes in urine, there Renal anemia, electrolyte imbalance, compared with the control group significant difference (P lt;0.05), compared with the indicators of the treatment group model group were significantly improved (P lt;0.05). Conclusion Niaoduqing enema can delay renal failure in rats adenine CRF model to simulate the process. [Keywords:] Renal Failure; uremic cooling off enema; pharmacology Niaoduqing enema is based on years of experience in the clinical application of traditional Chinese medicine developed traditional Chinese medicine prescription for civil prescription, a diuretic, anti-inflammatory, electrolyte imbalance and so on to improve, in order to clarify its role, this role will be to the side of the pharmacodynamic study provide a reference for clinical treatment. 1 Materials and methods 1.1 Materials 1.1.1 Niaoduqing enema test article, from rhubarb, SJ, Caulis Lonicerae other traditional Chinese medicine composition, 3 g crude drug / ml, made by the laboratory, batch number 070603; renal failure Guanchangye, Hainan Tianyuan Pharmaceutical Factory, batch