nm23 gene in human lung carcinoma and its clinical significance.doc

 PAGE \* MERGEFORMAT 12 nm23 gene in human lung carcinoma and its clinical significance [Abstract] Objective: To investigate the nm23 gene in human lung cancer and its relationship with the biological behavior of lung cancer. Methods: Immunohistochemical UltrasensitiveTMS P three-step method to detect 49 cases of lung cancer and 40 cases of adjacent normal lung tissue nm23 protein expression in sections, and combined with clinical data, applied statistical methods and its clinical biological behavior of lung cancer were analyzed. Results: In 49 patients with lung cancer, nm23 protein expression was 55.1%, significantly lower in normal lung tissue 87.5% (P lt;0.01); the pathological grade high grade, poorly differentiated and undifferentiated carcinoma nm23 protein expression rates were 82.6%, 41.2% and 11.1%, a statistically significant difference (P lt;0.01); in different age, gender, smoking index, lymph node metastasis and TNM staging, nm23 protein expression was no significant difference (Pgt; 0.05). CONCLUSION:: nm23 protein expression levels with lung cancer higher degree of differentiation increased, and may not be associated with the inhibition of lung metastasis [Keywords:] Immunohistochemistry; lung cancer; nm23 gene; degree of differentiation Died of lung cancer has become one of the major human cancer. In China, lung cancer incidence and mortality increase rapidly. Cancer prognosis and diagnosis of TNM stage. Lung cancer development is a multi-gene participation, multi-stage occurs , long form of the extremely complex disease process. nm23 gene is a more recent study of tumor metastasis suppressor gene, but for now, nm23 protein gene transfer, directly or indirectly regulate the mechanisms are not yet clear, nm23 protein expression with non-small cell lung cancer and the prognosis is not clear conclusion. In this study, patients with lung cancer by detecting the expression of nm23 protein in lung cancer and the relationship between biologic