Notch1 and Hes1 Hes5 in astrocytomas and correlation of expression.doc

 PAGE \* MERGEFORMAT 11 Notch1 and Hes1 Hes5 in astrocytomas and correlation of expression Of: Chunhua ZHENG Zhi MATRIX, Yang Weizhong, Chen Chun United States [Abstract] Objective To investigate the Notch1 receptor and its downstream signaling molecules Hes1, Hes5 in the human brain astrocytoma and its related expression. Methods Immunohistochemistry was used to detect 62 cases of astrocytic tumors and 7 cases of normal brain tissue Notch1 and Hes1, Hes5 expression. Results astrocytoma group of Notch1, Hes1 and Hes5 expression were significantly stronger than normal brain tissue group (P lt;0.05). at all levels of astrocytoma, the expression of Notch1 and Hes1 grade ~ were significantly higher than the level (P lt;0.05), Hes5 expression in the two groups no significant difference (Pgt; 0.05). astrocytoma group in the expression of Notch1 Hes1 good agreement (k = 0.503), consistent with the expression of Hes5 poor (k = 0.216). Conclusion Notch1 expression and the occurrence of astrocytomas, and astrocytomas histological grade. Notch1 may be mainly Hes1 but not Hes5 through downstream molecules play a role. [Keywords:] protein signaling gene expression in astrocytoma brain tumor cells by immunohistochemistry Notch signaling in the nervous system during development of the regulation of cell proliferation and differentiation play a crucial role. The signaling pathway with a variety of nervous system disorders are closely related to tumor formation [1]. Glial cell tumors are the most common primary brain tumors, It has been reported in glioma tissue and glioma cell lines were detected in the abnormal expression of Notch1 receptor [26], but Notch signaling pathway in the main downstream signaling molecules Hes1 and Hes5 expression in gliomas and its correlation with glioma, the relevance of the development and mechanism of action remains unclear. In this study, immunohistochemistry detected by Notch1 and Hes1, Hes5 in normal brain and astrocytoma tiss