NSCLC in the WWOX protein erbB2 protein and its relationship with cell proliferation.doc

 PAGE \* MERGEFORMAT 8 NSCLC in the WWOX protein erbB2 protein and its relationship with cell proliferation On: Sun Li Hua Liu Fang Yang Cuijun [Abstract] Objective To explore health in the elderly population in Zhangjiakou area CYP1A1 gene Msp polymorphism. Methods allele-specific polymerase chain reaction amplification and restriction fragment length polymorphism (PCR RFLP) technique, analysis of 360 cases Zhangjiakou region of the CYP1A1 gene in healthy adults 3 ‘end of the restriction enzyme Msp sites of the distribution of genotype 3. Msp results of the control group, 35.8% TT genotype, TC genotype 50.2%, accounting for 14.0 CC genotype % TC alleles were 60.9%, 39.1%; the experimental group Msp 34.0% TT genotype, TC genotype 51.2%, 14.8% CC genotype and allele T, C 59.6%, respectively, 40.4 %. Conclusion Zhangjiakou region genes of healthy elderly population CYP1A1 Msp polymorphism in healthy young people with no significant difference. [Keywords:] cytochrome P4501A1; allele; gene polymorphism; Msp CYP1A1 is a cytochrome P (CYP) 450 super-gene family, is the exogenous and endogenous compounds in Phase metabolism enzymes important one, in a variety of exogenous and endogenous chemicals in the body metabolism (1). Today, have been found polymorphic CYP1A1 gene MSP different race, age, ethnic and regional differences in the distribution, and have reported some of its polymorphisms and the incidence of cancer-related (2). CYP1A1 gene is mainly distributed in lung, kidney , gastrointestinal tract, skin, placenta and other tissues, the endogenous and exogenous compounds in the metabolism of the body play an important role, mainly through oxidation, reduction, hydrolysis and so on, change the compounds with the functional groups, or to break down. CYP1A1 mainly involved in polycyclic aromatic hydrocarbon compounds (PAH) metabolism, its metabolic activity is very strong phenolic epoxide, the epoxide in the carcinogenic, mutagenic important role