Nsubstituted benzyl chloride hydride haloperidol on rat hemodynamics.doc

 PAGE \* MERGEFORMAT 13 Nsubstituted benzyl chloride hydride haloperidol on rat hemodynamics Author: HE Xiao-ying, Wang Jinzhi, Zheng Jinhong [Abstract] Objective To study the hydrogenation of N  haloperidol substituted benzyl chloride (FB8 ~ FB11, FB13) on the hemodynamics in anesthetized rats and analyze the structure-activity relationship. Method of anesthesia normotensive SD rats by right common carotid artery to the left ventricle, the right femoral artery after intravenous injection of the respective compounds for different purposes, BL  420-type experimental system of biological function recorded observation of hemodynamic effects. The results compared with the previous administration, FB9 and FB11 The mean arterial blood pressure decreased significantly (P amp;lt;0.01); FB13 group lower (P amp;lt;0.05) at the same time, heart rate, left ventricular systolic pressure and left ventricular pressure change in a significant reduction in the maximum rate of . Conclusion FB9 and FB11 has a strong antihypertensive effect on cardiac function in rats had no effect; FB13 can lower blood pressure, and may have inhibitory effect on the heart. [Keywords:] Haloperidol; hydride; hemodynamics; structure-activity relationship Abstract: Objective To study the effects of n  substituted benzyl of hydrohaloperidol chlorides on hemodynamics in rats and analyze structure-activity relationship.Methods Catheters were inserted into the right femoral artery and the left ventricle through right common carotid artery. After iv administration of different compounds in anaesthetized rats, hemodynamic indexes were analyzed with BL  420 biology enginery experiment system. Results Compared with corresponding pre  treatment periods, the MAP at the 1 ~ 5 min significantly decreased in FB9 and FB11 group (P amp;lt;0.01). FB13 group has the effect of decreasing MAP (P amp;lt;0.05), HR, LVSP and ± dp / dtmax on anesthetized rats. Conclusion Pharmacological studies in vivo sugge