nt signaling pathway and breast cancer.doc

 PAGE \* MERGEFORMAT 19 nt signaling pathway and breast cancer Abstract Wnt signaling pathway in some tumors has an important role in the main text discusses Wnt signaling pathway and the relationship between breast cancer and the current carried out for the Wnt signaling pathway in breast cancer research. Keywords: breast cancer Wnt signaling pathway Breast cancer is the serious impact on women’s physical and mental health diseases, the pathogenesis of complex, but the real cause is not clear. At present, the occurrence and development of breast cancer recognized concluded: ① in the mammary epithelial cells in the process of carcinogenesis may have different genes are involved; ② after the formation of oncogenes in breast cancer still have a role. Wnts genes regulated by the Wnt signaling pathway, by Wnt protein in the cell surface receptors with their combination of complete cell growth, development of signal transduction. In recent years, studies have found, Wnt signaling pathway and breast cancer have a close relationship. 1 Wnt signaling pathway 1.1 Wnt signaling pathway in the composition of Wnt pathway members involved include: Wnt proteins, Frizzled (Fz), E-cadherin, β-catenin, GSK-3β, Dsh (Dishevledr), APC, Axin, Tcf / Lef, Ub (Ubiquitin), in these members , Wnt protein in combination with the Fz switch from the role of the entire pathway; β-catenin is a key component of the pathway, both can be combined with E-cadherin, but also with Tcf / Lef binding, but also with the GSK-3β, APC, Axin complex combination of all three, through a combination of different components, β-catenin in the cytoplasm and the nucleus of the level of change, thus affecting the expression of certain genes. E-cadherin: a prominent protein on the cell membrane, enabling cell adhesion with each other. Frizzled: Wnt protein in cell-surface receptor, its amino-terminal extension of area is rich in tyrosine, located outside