Of arsenic trioxide on human gastric carcinoma transplanted subcutaneously in nude mice the role of the mechanism.doc

 PAGE \* MERGEFORMAT 2 Of arsenic trioxide on human gastric carcinoma transplanted subcutaneously in nude mice the role of the mechanism Author: Liang, Gao Yong Li, Zhao Yuanyuan, Ru-Yong Yao, Shang Jun, GAO Shi-fang, Hu Xiaoxiao [Abstract] Objective: To explore the different doses of As203 on human gastric cancer cell line SGC  7901 subcutaneous tumors in nude mice in vivo anti-tumor effect and its mechanism. Methods: To establish a human gastric carcinoma transplanted subcutaneously in nude mice were randomly divided into experimental group that As203 low (1.0 mg / kg) in (2.5 mg / kg) of high (5.0 mg / kg) dose group and blank control group and positive control saline 5  FU group (20 mg / kg), intraperitoneal administration of a continuous 10 d, calculate inhibitory rate, detection of liver and kidney function after treatment of nude mice, and blood routine, observe the changes in body weight before and after treatment of nude mice, real-time quantitative RT  PCR detection of caspase  3 xenografts in the relative gene expression. Results: Low-dose group and As203 5  FU group inhibition rates were 60.6% and 78.2%, compared with the saline group had statistically significant difference (P