Of culture conditions on the inhibition of Candida albicans of amphotericin B Effect.doc

 PAGE \* MERGEFORMAT 8 Of culture conditions on the inhibition of Candida albicans of amphotericin B Effect Author: Liu Liying, Dong Xiaoqing, Wang Myint-U [Abstract] Objective comprehensive survey of a variety of factors (different medium, the medium pH, fungal inoculum concentration, etc.) on the role of AmB inhibitory effects of Candida albicans, in order to provide a theoretical basis for the clinical rational use of drugs. Methods of liquid dilution method. Results in a different medium, AmB against Candida albicans MIC value is different, with the higher pH bacilli and fungal inoculation increased concentration increase in the value of its MIC. Conclusion AmB on Candida albicans MIC value is affected by many factors, therefore, the antimicrobial activity of drug should be formulated and strictly enforce uniform standards. [Keywords:] amphotericin B; Candida albicans; inhibition [Abstract] Objective To investigate the effects of various factors, such as the type of medium, Ph of medium, size of inoculum on the activity of amphotericin B (AMB) against Candida albicans, so as to provide evidences for rational use of the drug . Methods The broth dilution test was examined.Results The activity of AmB against Candida albicans was influenced by the type of medium.The minimum inhibition concentrations (MIC) increased with the increase of pH and inoculum concentration. Conclusion The study of antifungal activity must establish and strictly implement unified standard. [Keywords:] amphotericin B; Candida albicans; inhibition Antifungal activity of drugs is affected by many factors, such as a different medium, the medium pH, incubation time, temperature, fungal inoculum concentration, fungal morphology, serum, aerobic and anaerobic environment. Amphotericin B is the clinical application of antifungal drugs, this study is a comprehensive study of various factors on the inhibitory effect of the impact of Candida albicans for the clinical use of drugs and to furth