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2017-05-05 发布于浙江
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Of magnesium on isolated rat myocardial ischemia-reperfusion in the role of.doc

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Of magnesium on isolated rat myocardial ischemia-reperfusion in the role of

Of magnesium on isolated rat myocardial ischemia-reperfusion in the role of Author: Chun-Ping Chang, Toh love, Guo Yimin, LIU Chong-Bin, Yu Liqun [Abstract] Objective: To observe the ischemia-reperfusion after 5 min application of magnesium is capable of in vitro ischemia-reperfusion myocardial protective effects. Methods: Langendorff isolated heart ischemia-reperfusion model of left anterior descending coronary artery ligation, ischemia 20 min, reperfusion for 60 min, the high magnesium group at 5 min reperfusion, when applied concentration of 2.4 mmol / L, 4.8 mmol / L, 8.4 mmol / L of the high-magnesium KH perfusion 10 min. Observation of cardiac hemodynamics, myocardial homogenate end of the experiment measuring MDA, immunohistochemical detection of SOD content. Results: ① 15 min reperfusion, when three high-magnesium group LVSP, LVDP * HR, LV ± dp / dtmax was significantly lower than ischemia-reperfusion group. ② 60 min reperfusion, when three high-magnesium group each indicator compared with the ischemia-reperfusion group difference was not significant. ③ three high-magnesium group was significantly lower than MDA content in ischemia-reperfusion group, SOD expression was significantly higher than ischemia-reperfusion group. Conclusion: Ischemia-reperfusion 5 min application of high-magnesium KH solution on myocardial ischemia-reperfusion in the performance of real-time to curb the role of the heart hemodynamics, measured at the end of reperfusion, MDA content in shows have a protective effect of magnesium on the heart, reflecting the anti - lipid oxidation. [Keywords:] high-magnesium; myocardium; ischemia-reperfusion Abstract: Objective: To investigate the role of high magnesium on rat isolated hearts after 5 min of ischemia / reperfusion. Methods: Cardiac hemodynamics indicators were analyzed with the Langendorff method in rat’s isolated heart. MDA was further determined in the experiment. All isolated hearts were subjected to 20 min of ischemia f