Of tea polyphenols on alcoholic liver injury in rats.docVIP

 PAGE \* MERGEFORMAT 8 Of tea polyphenols on alcoholic liver injury in rats [Abstract] Objective To establish a rabbit model of alcoholic liver injury pathology, of tea polyphenols on the treatment of alcoholic liver injury. Methods Rabbits were divided into 4 groups: control group, the low TP dose group, middle dose and high dose group. polyphenols of low, medium and high groups were administered the concentration of 10,20,40 mg / ml of TP solution treatment, experimental period of 2 weeks. determination of liver superoxide dismutase (SOD activity , malondialdehyde (MDA content and production of paraffin sections of liver tissue, HE stain, ordinary light microscope. The results can directly reduce the MDA content of polyphenols, and the medium dose (20 mg / ml and high dose (40 mg / ml effective way to remove active oxygen and free radicals. Conclusions of tea polyphenols on alcoholic liver injury have good treatment and protection. [Keywords] tea polyphenols, liver damage, superoxide dismutase, malondialdehyde Tea polyphenols extracted from one of the active ingredients from a variety of phenolic composition, is a polyphenolic compounds, free radical scavenging and antioxidant effects of biological activity. Marnewick [1] also found that Rats fed with green tea and black tea, the liver tissue were significantly decreased concentrations of oxygen free radicals. The experiment tried to establish the pathological model of alcoholic liver injury, the use of tea polyphenols treatment methods, histology and pathology from the perspective tea polyphenols in alcoholic liver injury in the treatment of play, and study its mechanism. 1 Materials and methods 1.1 Materials 98% of the polyphenols 15g, superoxide dismutase kit (Nanjing Jiancheng Biological Engineering Company, malondialdehyde kit (Nanjing Jiancheng Biological Engineering Company. 1.2 Animals and grouping 3 month old female white rabbits were 24 and body mass 1 ~ 1.5 kg, physical heal