Olfactory ensheathing cells and central nervous system injury and repair.docVIP

 PAGE \* MERGEFORMAT 37 Olfactory ensheathing cells and central nervous system injury and repair Keywords: olfactory ensheathing cells and central nervous system injury Central nervous system injury, especially spinal cord injury repair, the medical profession is still a problem. The reason is that the regenerative capacity of central nervous system and the external environment on the low axonal regeneration in vivo. At home and abroad a large number of experiments have been carried out to study the central nervous system damage fix the problem. These studies mainly from the following aspects: the inhibition of nerve growth antagonistic environment; to stimulate axon regeneration; cell transplantation. To the transplanted cells types: glial cells, including Schwann cells, glial cells, oligodendrocytes or their precursor cells, olfactory ensheathing cells; neural stem cell; embryonic tissue; gene-modified fibroblasts. Of these, olfactory ensheathing cell transplantation is considered one of the most promising means of scholars attracted widespread interest, carried out a large number of experimental studies and achieved remarkable results, and in early clinical trials [1 ~ 3] have made with some success. However, with in-depth research, some academics have already put forward after olfactory ensheathing cell transplantation for evidence of the failure of central nervous system injury and repair. This is the olfactory ensheathing cells can promote axon regeneration and functional recovery in this generally accepted notion of the tremendous challenge. This article will focus in recent years, olfactory ensheathing cells for repair of central nervous system injury in the rat are reviewed. A function of olfactory ensheathing cells Olfactory ensheathing cells in the olfactory system, with the support of life-long neurogenesis function. In the olfactory nerve injury or in normal cells, the update process, the new-born olfactory neuro