On ginsenoside Rg1 Rb1 on the secretion of amyloid precursor protein metabolism of enzymes.docVIP

 PAGE \* MERGEFORMAT 13 On ginsenoside Rg1 Rb1 on the secretion of amyloid precursor protein metabolism of enzymes Of: Wei Cuibai, Jian-Ping Jia, Wang Fen, Gu Longfei [Abstract] Objective ginsenoside Rg1, Rb1 on the amyloid precursor protein metabolism in the @ secretase activity and gene expression. Methods transfected with mutant PS1 (ML46L) and wild-type PS1 in CHO cells by luciferase mark @ secretase activity was detected, Western blot Western blot, RT-PCR to detect @ secretase gene ADAM9, ADAM10 protein and RNA expression. Results transfection of mutant PS1 ML46L Group @ secretase activity compared with transfected wild-type PS1 ( WT group) lower (P lt;0.05), addition of ginsenoside Rg1, Rb1 mutant PS1ML46L transfected group than @ secretase activity level is not plus different groups increased (P lt;0.05), while ADAM9, ADAM10 protein and RNA expression group than those without addition of different levels increased (P lt;0.05). Conclusion Ginsenoside Rg1, Rb1 may be increased to different degrees @ secretase in ADAM9, ADAM10 gene expression, increased @ secretase activity, and regulation of ginsenoside Rg1 excellent in ginsenoside Rb1. [Keywords:] ginsenoside Rg1, ginsenoside Rb1, amyloid precursor protein secretase; Alzheimer’s disease Keywords:: Ginsenoside Rg1, Ginsenoside Rb1, secretase of amyloid precursor protein, Alzheimer’s Disease β-amyloid protein (beta-amyloid protein, Aβ) deposition in extracellular senile plaques are composed of Alzheimer’s disease (Alzheimer’s Disease, AD) one of the main pathological features. Aβ from the amyloid precursor protein (amyloid precursor protein , APP) by @ and β secretase cleavage of the two. effectively adjust the secretory activity and function is an important way to control AD. Ginsenoside Rg1, Rb1 is the main active ingredients of ginseng. There are reports, ginsenoside Rg1, Rb1 have antioxidant, inhibiting apoptosis, anti-excitatory amino acid toxicity and an increase in the effective i