On c myc in nasal inverted papilloma and clinical significance of the expression.docVIP

 PAGE \* MERGEFORMAT 10 On c myc in nasal inverted papilloma and clinical significance of the expression [Abstract] Objective: To study the proto-oncogene c myc in nasal inverted papilloma (SNIP) expression and clinical significance, in order to be able to find the c myc and the occurrence of SNIP. METHODS: Department of Pathology, Central Hospital of Wuhan, 2000 ~ 2007 archive nasal inverted papilloma in 20 cases of paraffin, the other around the tumor tissue taken as control tissue in 5 cases, by immunohistochemistry SP method detected c  myc-related antigen. under the microscope (× 400), each measured positive perspective, the average optical density of positive area and total area of #8203;#8203;all cells, the positive area ratio calculation. HPIAS 2000 using high resolution color graphic pathology report management system c Myc expression in each group for quantitative analysis. Results : SNIP in the expression of c Myc average optical density of 0.3290 + -0.0218, c Myc expression in the control group, the average optical density of 0.0854 + -0.0112; SNIP c  Myc expression in the positive area was 0.2873 + -0.0152, the control group c Myc expression in the positive area was 0.0754 + -0.0124, SNIP and the control group (P lt;0.05), the difference was significant. Conclusion: c  myc in nasal inverted papilloma in the high expression of help SNIP diagnosis. [Keywords:] c myc; nasal inverted papilloma; immunohistochemistry; correlation Sinonasal inverted papilloma (sinonasal inverted papilloma, SNIP) occurred in the nasal cavity and paranasal sinus mucosal epithelial benign tumor, the histopathology was benign, but with the malignant behavior, showing invasive growth, local destructive Strong, easy to relapse and malignant, it was reported the recurrence rate from 30% to 78%, and malignant transformation rate from 5% to 21% [1], the factors influencing its occurrence and clinical pathologists have been the focus of attention . proto-oncogene c myc