On inhibin B and male infertility.docVIP

 PAGE \* MERGEFORMAT 12 On inhibin B and male infertility [Keywords:] Inhibin B male infertility Male infertility is a worldwide plague many couples of reproductive age is an important issue. Due to the current lack of regulation of spermatogenesis and its profound understanding of, and infertility by genetic, environmental and other factors, so male infertility correct diagnosis and treatment are male scientists are often faced with clinical problems. In recent years, a variety of male science laboratory in clinical diagnosis of new technology gradually, inhibin B (inhibin B) Detection of the level of fertility for infertile patients provided an assessment a more effective serum marker. I. Overview of inhibin B 1. The structure of inhibin B: inhibin is a 32 KD molecule glycoprotein peptide hormones, are transforming growth factor β (TGF-β) peptide family [1], by the α subunit (18KD) and β subunit base (14KD), linked together by disulfide bonds heterogeneous dimer. where β subunits βA, βB two forms, to form INH A (inhibin A, inhibin A) (@ βA) and INH B ( inhibin B, inhibin B) (@ βB). In men, INH A very few, have important physiological functions that INH B [2]. 2. The source of inhibin B: gonadal development in patients with disorders or orchiectomy is generally difficult to detect in blood INH B, suggest that male body may be derived from testicular INH B [3]. By immunohistochemistry and in situ hybridization showed inhibition elements of the βB subunit in germ cells and Sertoli cells were positive, so that the INH B is a germ cell and Sertoli cell interaction products. and the child during the INH B is considered to only occur on the Scioto Lee (sertoli) cells [4]. Second, inhibin B and male infertility 1. Male inhibin B secretion in vivo: INH B secretion in the regulation of more complex, with the occurrence and development stages of individual differences. In the embryonic period and before puberty by follicle stimulating hormone (folli