On Salvia inhibit apoptosis after ischemia-reperfusion of the Research.docVIP

 PAGE \* MERGEFORMAT 5 On Salvia inhibit apoptosis after ischemia-reperfusion of the Research [Paper Keywords:] ischemia-reperfusion; Apoptosis; Salvia; traditional Chinese medicine; Review [Abstract] excessive apoptosis of cells involved in the ischemia-reperfusion injury (Ischimia reperfusion injury, IRI) from happening. China’s traditional Chinese medicine Danshen in cellular, molecular, genetic level of regulation of the occurrence of apoptosis in IRI, and thus IRI has a good preventive effect. In the liver, kidney, brain and other organs from ischemia-reperfusion injury (Ischimia reperfusion injury, IRI) resulting from the form of cell death, apoptosis is also a common and important form [1-4]. Once the necrotic cells, at present there is no means to interfere; but apoptosis is subject to a series of process control process, it is possible to die through intervention program to save it. Salvia confirmed by modern experimental techniques for the excessive cells during IRI inhibit apoptosis, the contents of this article shall be reviewed in this regard. 1 Danshen on inhibition of apoptosis in IRI Wu.W et al [5] the use of in situ cell apoptosis markers (terminal deoxynucleotidyl transferase mediated uridine nucleotide end labeling, TUNEL) experiment observed: the left middle cerebral artery occlusion in rats 24 h after the cerebral cortex, caudate nucleus, lentiform nucleus a large number of apoptotic cells in the ischemic region, 24 ~ 48 h reached a peak; a pre-given in the corresponding position of Salvia sees only a small amount of apoptotic cells; and compared with the control group, 24 h time period significantly reduced tissue damage. Salvia may be prompted apoptosis by reducing the nerve to play a protective effect on brain IRI. Salvia whether other organs also have a similar effect is not yet clear. 2 Danshen inhibited IRI when the mechanism of apoptosis 2.1 reduction in protease expression Cells in the central part of apoptosis is activa