On the 188 cases of hepatitis B virus pre-S2 antigen and its clinical significance.docVIP

 PAGE \* MERGEFORMAT 11 On the 188 cases of hepatitis B virus pre-S2 antigen and its clinical significance Paper Keywords: pre-S2 antigen; HBV-DNA; hepatitis B virus markers Abstract: Objective: To investigate the hepatitis B virus pre-S2 antigen (pre-S2Ag) Detection and clinical significance. Methods: 188 cases of samples using ELISA method for hepatitis B virus markers fHBV M1 and the pre-S2Ag testing, and of which 162 specimens using fluorescence quantitative-PCR detection of HBV-DNA. Results: 162 patients with simultaneous detection of serum HBV-DNA samples and pre-S2Ag, detection rate between the two no statistically significant difference (X2 = 2.78, Pgt; 0.05). HBeAg () and HBeAb () group between the pre-S2Ag positive rate was significantly (X2 = 28.03, P lt;0.005). HBeAg () group, HBclgM () group of pre-S2Ag positive rate of 100%, HBSAg () of the HCC group pre-S2Ag positive rate was 95.0%, significantly higher than the results of HBV-DNA (-) group 18.4%, P value both “0.005. Conclusion: pre-S2Ag reflects the viral infection and replication of the index, with clinical disease activity can be used as observation of efficacy and prognostic indicators, be able to improve and supplement the hepatitis B virus serum markers. China is the hepatitis B virus (HepatitiS B ViruS, HBV) infection in endemic areas, hepatitis B virus is the most common cause of hemolytic hepatitis viruses, not only the high infection rate. And some HBV infection may be due to peripheral tolerance, T cell response is low, inhibiting antigen presentation, selective immune suppression, viral gene expression or gene mutation down such barriers lead to T cell recognition, easy to chronic infection. Some patients may develop liver cirrhosis or primary liver cancer. A different mode of HBV serological markers in different clinical significance of tips, HBV-DNA is to determine whether the virus infected HBV replication and the current availability of key indicators of i