On the anti-hepatitis B virus nucleoside analogue resistance mechanisms.docVIP

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On the anti-hepatitis B virus nucleoside analogue resistance mechanisms.doc

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On the anti-hepatitis B virus nucleoside analogue resistance mechanisms

On the anti-hepatitis B virus nucleoside analogue resistance mechanisms Paper Keywords: Hepatitis B virus; lamivudine; resistance mechanisms; combination therapy; nucleoside analogues Abstract: Objective: The hepatitis B treated with lamivudine resistance mechanisms and clinical responses were summarized. Methods: The literature search in recent years, an overview of evaluation. Results: Lamivudine treatment of chronic hepatitis B infection in a wide range of drug-resistant mutations. Conclusion: The current treatment of chronic hepatitis B infection in the efficacy of drugs less than ideal, should be based on the specific circumstances of each patient using multi-channel, multi-target integrated therapy. Lamivudine as an anti-hepatitis B virus (HBV) in first-line drugs have been widely used in clinical, but as a long-term clinical application, HBV mutation is increasingly prominently exposed. In this paper, the mechanism of action, drug-resistant mutations and clinical aspects of the response to elaborate. A mechanism of drug lamivudine Lamivudine primarily by inhibiting the HBV-DNA polymerase to inhibit HBV-DNA replication role. Intracellular phosphorylation of lamivudine in lamivudine 3 as phosphate (L-TP), and in the form of cyclic adenosine phosphate by HBV viral DNA polymerase embedded in competing with the incorporation of cytidine acid HBV-DNA chain synthesis, leading to synthesis of DNA chain termination. In the hepatitis B virus replication process, the pre-genomic RNA as a template RT full-length HBV-DNA negative stocks, this step is similar with the retrovirus. Lamivudine is also a reverse transcriptase inhibitor, can effectively prevent the viral nucleic acid synthesis. In patients with chronic hepatitis B patients with decompensated cirrhosis, lamivudine antiviral therapy can also inhibit liver fibrosis and improve liver function [1], multi-dimensional improvement of liver tissue in patients with chronic hepatitis B and reduce liver cirrho