On the kidney and nourishing marrow aplastic anemia of chronic IL-3 SCF IFN-γ TNF-αmRNA expression.docVIP

 PAGE \* MERGEFORMAT 12 On the kidney and nourishing marrow aplastic anemia of chronic IL-3 SCF IFN-γ TNF-αmRNA expression Of: Xurui Rong, Wang Yan, An Yu-Ji, in Zhifeng, Dai Ximeng [Abstract] Objective To observe the kidney and marrow of Chinese medicine on patients with chronic aplastic anemia factor expression in hematopoietic regulation, and to explore the regulatory mechanism of kidney medicine. Methods 120 patients were randomly divided into the kidney and nourishing marrow treatment group 90 cases , comparison group, 30 cases, an alternative voluntary offer marrow by bone marrow in 10 cases as normal healthy control group. by RT-PCR method to observe the bone marrow hematopoietic cell regulators of stem cell factor (SCF), interleukin 3 (IL-3) , tumor necrosis factor @ (TNF-@), interferon γ (IFN-γ) mRNA expression semi-quantitative. Results Before treatment, patients were SCF, IL-3 expression was significantly lower than the healthy group (P lt;0.01) After treatment, increased (P lt;0.05), treatment group was higher before treatment TNF-@, IFN-γ expression was significantly higher than healthy group (P lt;0.01), decreased after treatment (treatment group P lt;0.01 the control group, P lt;0.05), the treatment group than the control group (TNF-@ P lt;0.01, IFN-γP lt;0.05). Conclusion kidney nourishing marrow disorder herbal medicine can regulate the immune status, and enhance the role of positive regulatory factors, negative regulator to lift too much on the excessive inhibition of hematopoietic cells for therapeutic purposes. [Keywords:] aplastic anemia, kidney and nourishing marrow, hematopoietic regulation, cytokine Abstract: Objective To observe the effect of chronic aplastic anemia patients treated with promoting kidney and tonifing bone herbs on the expression of hematopoiesis regulation factors, and discuss the mechanism of kidney-promoting herbs. Methods 120 cases of chronic aplastic anemia were randomly divided into two groups, 90 cases