Oxaliplatin in combination with camptothecin treatment of 32 cases of elderly patients with gastric.docVIP

 PAGE \* MERGEFORMAT 12 Oxaliplatin in combination with camptothecin treatment of 32 cases of elderly patients with gastric Of: universal Gao-Feng Li Ning Huang Yuesheng Wang Chaoyang [Keywords:] hydroxy camptothecin, oxaliplatin, fluorouracil / leucovorin, advanced gastric cancer Most of the clinical treatment when patients with gastric cancer is already advanced, they can not not satisfied with surgery or surgery, chemotherapy is an important method of treatment. With fluorouracil (5 FU) is a joint program of standard treatment for gastric cancer, and its side effects is the limiting factor of chemotherapy, affecting quality of life of patients, particularly the general situation of the elderly poor in patients with advanced gastric cancer. So explore for elderly patients with advanced gastric cancer is safe and effective combined chemotherapy is very necessary. In this study, HCPTOX programs and FOLFOX4 regimen in the treatment of advanced gastric cancer aged 60 cases, the two programs were observed and compared the efficacy and toxicity. 1 Materials and methods 1.1 study January 2002 to January 2006 our hospital for advanced gastric cancer aged 60 cases were diagnosed by pathology. Pathologic types: 26 cases of poorly differentiated adenocarcinoma, moderately differentiated adenocarcinoma in 23 cases, 8 cases of mucinous adenocarcinoma , 3 cases of signet ring cell carcinoma, 40 cases were male, 20 females, aged 66 to 84 years, median age 72 years. that is not used to oxaliplatin (OXA) or hydroxycamptothecin (HCPT), treatment time from last 1 month or more. Kamofsky scoregt; 60 points, with measurable lesions, expected survival timegt; = 3 months. Before treatment, blood, liver and kidney function was normal .60 patients were randomly divided into 2 table method group, HCPTOX 32 cases, FOLFOX4 group of 28 patients, the general characteristics of the two groups were compared, no significant difference (Pgt; 0.05. 1.2 Treatment HCPTOX