p53 gene in bladder cancer research.docVIP

 PAGE \* MERGEFORMAT 13 p53 gene in bladder cancer research Authors: Cao Yu, Coulee m heat, Zhang Zheng-biao [Abstract] p53 gene is found so far the highest of human tumor-associated genes. p53 gene and 50% of human tumors, as a tumor suppressor gene, p53 gene mutation and cancer are closely related to the production. Mutations of the p53 protein in urinary tract tumors in a high rate of positive expression, with a high prognostic value; In addition, p53 gene and its products, and other ties is of great significance. This paper reviews the p53 tumor suppressor gene and mutation underlying carcinogenic mechanism, discussed the p53 in bladder cancer research in the status quo and prospect of gene therapy application. [Keywords:] p53; bladder cancer; mutation; gene therapy [Abstract] So far as we know, p53 gene, which is responsible for 50% human cancer, has the closest relationship with cancer.As a tumor suppressor gene, the mutations of p53 play a vital role in the generation of tumor.The mutational p53 protein has been found a high positive expression rate in the tumor of urinary system, and has been shown great value in prognosis.In addition, the interactions between p53 and other genes or their products are of significance according to recent researches.In this article , the basic mechanism has been summarized as suppression of cancer addressed by p53 protein and the generation of cancer related with mutations of p53 gene, and the research progress on p53 gene in bladder cancer as well as the applicable prospect of p53 related gene therapy in bladder cancer has also been discussed. [Keywords:] p53; bladder cancer; mutation; gene therapy As the molecular biology and related disciplines, developments in the bladder cancer gene research, people also made a number of important results. In all tumor suppressor gene, p53 gene is the most watched one, wild-type p53 gene and cell cycle growth regulators, the regulation of cell transformation, DNA replication, a