Paeonol in diabetic rats on prostacyclin and thromboxane A2 endothelin nitric oxide.docVIP

 PAGE \* MERGEFORMAT 9 Paeonol in diabetic rats on prostacyclin and thromboxane A2 endothelin nitric oxide Of: Min Cun-Yun, Liu Qiang, Zhan Feng, Wei Zhong Qiu [Abstract] Objective To investigate the Pae in diabetic rats prostacyclin (PGI2), thromboxane A2 (TXA2), endothelin (ET), nitric oxide (NO). Methods by intraperitoneal injection of streptozotocin (60 mg / kg) in diabetic animal models were prepared, and then were high, medium and low doses of paeonol different rats were fed on by radioimmunoassay before and after treatment of rats PGI2, TXA2 , ET, NO. Results of the treatment group before and after treatment no significant changes in blood sugar, compared with the control group, no significant difference ,6-Keto-PGF1 @ (pg / mL) respectively by 89.75 + -2.75,89.97 + -7.28,89.97 + -11.36 rose to 120.03 + -13.85,108.34 + -11.25,105.32 + -8.85, compared with the control group, there were significant differences. The treatment group rats TXB2 (pg / mL) respectively 157.64 + -10.36,156.64 + -11.35,153.33 fell 124.46 + -19.40 + -22.20 + -18.67,136.40 + -18.15,138.40 the high dose group decreased most Obviously, the treatment group rats ET (pg / mL) respectively 181.68 + -4.19 + -5.10,181.27 + -4.76,181.04 fell 140.55 ± 3.01,150.51 + -2.22,161.02 + -3.76, where the high dose group The most obvious, compared with the control group, there were significant differences in the treatment group increased slightly, NO value, but compared with the control group, no significant difference. Conclusion of diabetic rats paeonol ET, 6-Keto-PGF1 @, TXB2 have an impact. [Keywords:] paeonol; diabetes, vascular endothelial cells, rat Abstract: Objetive To study the effect of Paeonol on PGI, TXA2, ET and NO in diabetic rats. Methods Streptozocin was used in dosage of 60 mg / kg on rats to make diabetic animal model. Defferent dosages of Paeonol were used on diabetic animal models . 6-Keto-PGF1 @, TXB2, ET and NO were tested after 30 days. Results Compared to the cont