Paclitaxel liposome injection in rabbits and the pharmacokinetics behavior of relatively.docVIP

 PAGE \* MERGEFORMAT 11 Paclitaxel liposome injection in rabbits and the pharmacokinetics behavior of relatively [Abstract] Objective To compare the paclitaxel liposome (paclitaxel liposome, L  PAC) and injection (paclitaxel injection, I  PAC) in rabbits the pharmacokinetic behavior. Methods 12 rabbits were randomly divided into two groups, respectively, from the ear vein a single dose (12 mg * kg  1) injection of L  PAC, and I  PAC, using HPLC determination of plasma concentrations at each time point, with DAS2.0 and SPSS13.0 software processing and analysis of data. The results of two kinds of preparations  plasma concentration-time curves are in line with two-compartment model, the main pharmacokinetic parameters of t1/2α were (1.206 ± 0.205), (0.538 ± 0.236) h; t1/2β were (33.560 ± 6.685 ), (12.187 ± 1.255) h; Vd, respectively (0.619 ± 0.084), (0.809 ± 0.087) L; CL, respectively (0.035 ± 0.010), (0.096 ± 0.010) L * h-1; K10, respectively (0.043 ± 0.010), (0.134 ± 0.020) h-1; K12, respectively (0.245 ± 0.038), (0.777 ± 0.252) h-1; K21, respectively (0.321 ± 0.058), (0.594 ± 0.193) h-1; AUC0 -24, respectively (321.109 ± 18.462), (200.024 ± 22.937) mg * h * L-1; AUC0-∞ , respectively (722.195 ± 170.360), (272.300 ± 38.568) mg * h * L-1; two kinds of preparations The t1/2α , t1/2β , Vd, CL, K10, K12, K21, AUC0-24 and AUC0-∞ by the statistical analysis, there is a very significant or significant. Conclusion L  PAC and I  PAC than in rabbits in vivo pharmacokinetic behavior significantly different liposome with a long-lasting and sustained-release characteristics of the body in maintaining a longer cycle time, while better able to land concentration in the target tissue, reduction of drug toxicity to other organs and increase the efficacy. [Keywords:] Paclitaxel Liposome pharmacokinetics high performance liquid chromatography Pharmacokinetics differences between paclitaxel liposome and injection in rabbits after int