Pai hyperuricemia acid granules on serum uric acid levels in rats.doc

 PAGE \* MERGEFORMAT 6 Pai hyperuricemia acid granules on serum uric acid levels in rats Study: Fan Xiang-jun, Shiqiao Rong, Wang Dongwen [Abstract] Objective To study the row of hyperuricemia acid granules on blood uric acid levels in rats. Methods 60 rats were randomly divided into control group, model group, colchicine control group, group scheduling acid granules, the use of sub- xanthine induced hyperuricemia, observation rows of uric acid lowering effect of acid granules. results came acid granules hyperuricemia can significantly reduce the level of serum uric acid in rats. Conclusion row acid granules with the role of anti-gout. [Keywords:] Pai acid granules, hyperuricemia, rats, serum uric acid Pai acid granules skin by Qin, Phellodendron, Coptis and other components of the compound preparation of Chinese medicine, with the heat and dampness, expelling wind pain and other effects, mainly used for gout (wet-heat syndrome of depression treatment. Hypoxanthine this experiment caused a large Hyperuricemia rats, observation rows of uric acid lowering effect of acid granules. 1 Materials 1.1 Animals 60 Wister rats, male, weight 200 ~ 250g. 1.2 Drugs and reagents row acid granules made by the hospital; hypoxanthine: Sigma Corporation, specifications: 25g / bottle; niacin: Tianjin Lisheng Pharmaceutical Co., Ltd., Spec: 50mg; control drug colchicine: Xishuangbanna Xishuangbanna drugs Industry Co., Ltd., specifications: each containing colchicine 0.5mg. 2 Methods and Results 2.1 Grouping and dosing of 60 rats were randomly divided into control group, model group, positive control group, behind acid granule group, 15 rats in each group. Dose were as follows: row acid granules Group: 3.5 g / kg (35% 10ml/kg, positive control group (colchicine: 0.5mg/kg (5% 10ml/kg, blank control group, model group: fed the same volume of pure water [1]. 2.2 Experimental methods other than the control group, intraperitoneal injection of 3 groups of h