Panax Cordyceps powder mixture and the new mouse mammary tumor anti-vascular effects of.docVIP

 PAGE \* MERGEFORMAT 13 Panax Cordyceps powder mixture and the new mouse mammary tumor anti-vascular effects of Of: Zhang Yanming, Li Xiaoming, Chen Xinyi, XU Li [Abstract] Objective To observe the anti-mixed powder Cordyceps Panax transplanted mouse mammary tumor (EMT6) and its angiogenesis effect. Methods portability EMT6 mouse cell line, the culture and passage, with its inbred BALB / C Small tumor-bearing mice was transplanted animals, and to intervene Panax Cordyceps powder mixed in the tumor inhibition rate, based on the tumor with conventional paraffin embedding, sections were observed by immunohistochemistry of tumor microvessel density (MVD ), vascular endothelial growth factor (VEGF), tissue inhibitor of metalloproteinase-Ⅱ (TIMP-2) expression. The results of two experiments designed to dose the tumor inhibition rates were 48.95%, 37.64%, experimental two tumor MVD, significantly reduced VEGF expression, TIMP-2 expression was increased. Conclusion Panax Cordyceps powder mixture can inhibit mouse mammary tumor growth, inhibition of tumor angiogenesis might be one of the mechanisms. [Keywords:] Panax Cordyceps mixed powder, breast cancer, tumor microvessel density; vascular endothelial growth factor, tissue inhibitor of metalloproteinase-Ⅱ Abstract: Objective To observe inhibition rate of mouse mammary adenocarcinoma (EMT6) and inhibition effect on tumor angiogenesis of Panax notoginseng FH Chen and Cordyecps sinensis Sacc. Powder. Methods BALB / C mice as bearing cancer animals with subcultured mouse-transplantable EMT6 cell train had accepted intervention treatment by Panax notoginseng FH Chen and Cordyceps sinensis Sacc. powder. In this way, inhibition rate of the mouse-transplanted EMT6 by the powder was recorded and the expression of microvessel density (MVD), vascular endothelial growth factor (VEGF) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in the tumor tissue after paraffin imbedding and section were detected through immun