Panax japonicus saponin on cerebral ischemia-reperfusion model of hippocampal nitric oxide synthase.docVIP

 PAGE \* MERGEFORMAT 11 Panax japonicus saponin on cerebral ischemia-reperfusion model of hippocampal nitric oxide synthase Of: Zhao Hui, Zou Haiyan, Xu Meng, Xiao Yan Yuan, Xue Pu [Abstract] Objective To observe Panax japonicus saponin (total rhizoma panacis japonica saponins, tRPJS) on repeated cerebral ischemia in mice and rats after focal cerebral ischemia and reperfusion in hippocampus of nitric oxide synthase (NOS), inducible nitric oxide synthase (iNOS) explore the effect of drugs against cerebral ischemia in rats. Method of interpolation line method of middle cerebral artery occlusion (MCAO) rat model of focal cerebral ischemia, the use of repeated clipping bilateral common carotid artery approach in mice model of cerebral ischemia to study the tRPJS these two kinds of model of cerebral ischemia hippocampus NOS, iNOS effect. Results tRPJS can significantly reduce the cerebral ischemia reperfusion injury after focal cerebral ischemia in mice and hippocampus of NOS, iNOS levels (P lt;0.05) . Conclusion tRPJS against cerebral ischemia and reduced hippocampus NOS, iNOS in the activity. [Keywords:] Panax japonicus saponin, cerebral ischemia, nitric oxide synthase Abstract: Objective To study the mechanism of protective effects of total rhizoma panacis japonica saponins (tRPJS) on the cerebral ischemia injury. Methods The middle cerebral artery occlusion model (MCAO) in rats and cerebral ischemia-reperfusion models in mice were used to investigate the influence of tRPJS on the nitric oxide synthase (NOS) and inducible nitric oxide synthase (iNOS) activity in hippocampus region. Results tRPJS significantly decreased the contents of NOS and iNOS in hippocampus region of MCAO rat and cerebral ischemia reinfusion mouse. Conclusion tRPJS has significantly protective effects by decreasing NOS and iNOS. Keywords:: total thizoma panacis japonica saponins, cerebral ischemia, nitric oxide synthase A large number of studies have shown that nitric oxid