Panic disorder molecular genetics.docVIP

 PAGE \* MERGEFORMAT 15 Panic disorder molecular genetics Keywords:: panic disorder genes Abstract The etiology of panic disorder may be related to classical neurotransmitters GABA ,5-HT, DA, Ach and neuropeptide CCK and other dysfunction related to this article on patients with panic disorder near the GABA ,5-HT, DA, Ach and CCK receptor genes studies are reviewed. Keywords: panic disorder; gene Panic disorder is a recurrent severe anxiety. The current hypothesis to explain the mechanism of its causes are many hypotheses, including neurological and biochemical aspects of the classic neurotransmitters GABA ,5-HT, DA and Ach such dysfunction hypothesis, as well as the neuropeptides CCK and DA imbalance hypothesis and so on. Genetic factors in the occurrence of panic disorder may also play a role, because the right people along ethnic lines, stove survey found that close relatives of patients with anxiety disorders, the Benbingfasheng rate of 15%, which is three times the general population [1 ]; pairs of twins survey found that monozygotic twins with the disease rate was 50%, anxiety and quality of 65%, while the pairs of monozygotic twins with the disease rate was only 4%, anxiety and quality of only 13% [1]; these studies have shown that panic disorder has a clear genetic predisposition, which causes at least in part lies in the genes. With the development of molecular genetics in recent years at the gene level to the etiology of panic disorder to conduct a lot of research. I. GABAA receptor gene with panic disorder γ -aminobutyric acid (GABA) receptors are divided into two subtypes of GABAA and GABAB. GABAA receptor subtypes with the chlorine-pass values, stability and receptor form a complex, the complex from the α , β , γ , δ subunits of a tetramer, gated with chlorine-pass values. α -subunit there is a stable point; β subunit of GABA on the point of integration; γ subunit itself can not, and benzodiazepine class or GABA binding, but it is oli