Pachygyria malformation in 1 case.docVIP

 PAGE \* MERGEFORMAT 4 Pachygyria malformation in 1 case [Keywords:] pachygyria malformations A medical record Patients, male, 3 months to “twitch 2” main appeal is admitted. Examination: body temperature 36.7 , pulse 132 / min, breathing 35 times / min, not nervous before the skull, occipital bald positive, other blood, liver function were normal. limb muscle strength can still be made payable to worse. MRI scan showed: bilateral frontal and temporal lobe gyrus widened, increased cortical thickness, cortical surface is smooth, sulcus shallow, white matter changes thin, moderate expansion of bilateral lateral ventricle. diagnosis of pachygyria malformation. 2 Discussion Normal brain development, including neural tube formation, proliferation of the original cell differentiation, neuronal migration and myelin formation stage. Neuronal migration is a complex process, the first 6 weeks of fetal brain, from the original single-layer columnar epithelium of neural tube After differentiation, the formation of four basic fetal zone, split from the inside out ventricular zone, subventricular zone, intermediate zone and marginal zone, ventricular zone and subventricular zone cells to differentiate into various types of neurons function, also known as germinal grassroots level. about 7 weeks since the germinal grassroots progressive outward migration into nerve cells, migrating neurons in the formation of the earlier deep cortex, and late migration of neurons is the formation of the surface of the cortex. Finally, in embryos 6 months, the normal formation of the cerebral cortex of the 6 layers. In the transitional period, such as disruption caused by migration barriers, resulting in a range of deformities. neuronal migration disorder often characterized by abnormal development of the cortex, transitional obstacles occur sooner, the more severe deformities , the more symmetrical; and the more transitional disability in late, then the more minor malformations