Papillary thyroid carcinoma MMP9 and Ecadherin expression correlation.docVIP

 PAGE \* MERGEFORMAT 13 Papillary thyroid carcinoma MMP9 and Ecadherin expression correlation Of: Wang Bing Shang Ping Zhang Jinjiang training in the Valley of [Abstract] Objective: To investigate the papillary thyroid carcinoma (PTC) of matrix metalloproteinase 9 (MMP 9) and E cadherin (E cadherin) expression and tumor invasion and metastasis. Methods: Microwave Streptomyces biotin ( Microwave LSAB) method detected 69 cases of PTC tissue MMP 9 and E cadherin expression. Results: MMP 9 and E cadherin positive rates were 68.1% (47/69) and 30.4% (21/69), MMP 9 expression and PTC invasion and metastasis was positively correlated (P lt;0.05); E cadherin expression with PTC invasion and metastasis was a negative correlation (P lt;0.05). Conclusion: MMP 9 was highly expressed and E cadherin low expression may be involved in PTC in the development process, especially with the invasion and metastasis, combined detection of prognosis for PTC with clinical significance. [Keywords:] thyroid neoplasms; matrix metalloproteinase-9; E cadherin; tumor metastasis [ABSTRACT] Objective: To investigate the correlation of MMP 9 and E cadherin expression with the potential of invasion and metastasis in papillary thyroid carcinoma (PTC). Methods: The expressions of MMP 9 and E cadherin protein in 69 cases with PTC were studied by microwave labelled strept avidin biotin immunohistochemical method.Results: The positive rates of MMP 9 and E cadherin in PTC were 68.1% (47/69) and 30.4% (21/69) respectively.There was a positive correlation between MMP 9 expression and the tumor invasive and metastasic potential in PTC (P lt;0.05). There was a negative correlation between E cadherin expression and the tumor invasive and metastasic potential in PTC (P lt;0.05). Conclusion: Expression of MMP 9 and E cadherin protein were closely correlated with the invasive and metastasic potential in PTC.MMP 9 and E cadherin could be considered as prognostic indications for PTC. [KEY WORDS] T