Particle model of liver fibrinolysis in liver expression of PDGFBB.doc

 PAGE \* MERGEFORMAT 7 Particle model of liver fibrinolysis in liver expression of PDGFBB [Abstract] Objective To investigate the anti-particles of liver fibrosis fibrinolytic molecular mechanism for the prevention and treatment of hepatic fibrosis provide a theoretical basis for traditional Chinese medicine preparation. Approach to carbon tetrachloride (CCL4 high-fat low-protein complex of factors of ethanol-induced liver fibrosis rats as subjects, hepatic fibrinolysis particles (from Astragalus, Angelica, Panax, Fructus Mori Albae, turtle shell, donkey-hide gelatin composition on the model of rats. detected by immunohistochemistry in liver tissue of platelet-derived growth factor BB ( expression of PDGF BB. The results as the dose increased, the liver can significantly reduce particles in rats fibrinolytic PDGF BB expression, and with the positive control group was not significantly different (Pgt; 0.05), compared with the model group were significant and extremely significant difference. Conclusion particles can significantly reduce hepatic fibrinolytic PDGF BB expression in liver tissue, which may be particles of liver fibrinolysis mechanism of prevention and treatment of liver fibrosis. [Keywords:] liver fibrosis, immunohistochemistry, PDGF BB, liver fibrinolysis particles Liver fibrosis is the development of a variety of chronic liver disease a common pathological basis, its formation and development have an impact on prognosis of various liver diseases, the key outcome. Therefore, to effectively block the development of liver fibrosis prevention and treatment of cirrhosis of the liver is important . fibrinolysis liver particles (from Astragalus, Angelica, Panax, Fructus Mori Albae, turtle shell, composed of gelatin used in clinical prevention and treatment in our hospital of liver fibrosis has been for many years. In this paper, carbon tetrachloride (CCl4 high-fat low-protein ethanol complex factors induced liver fibrosis in rats to study the ob