Pancreatic kallikrein joint angiotensin-converting enzyme inhibitor treatment of diabetic microalbuminuria.doc

 PAGE \* MERGEFORMAT 7 Pancreatic kallikrein joint angiotensin-converting enzyme inhibitor treatment of diabetic microalbuminuria [Abstract] Objective: To observe the pancreatic kallikrein (TPK) combined angiotensin-converting enzyme inhibitor (ACEI) treatment of diabetic microalbuminuria in clinical effect. Methods: 60 subjects were divided into control and combination therapy group, after 12 weeks of treatment, testing before and after treatment 24 h urinary albumin changes in results: before and after treatment 24 h urinary albumin were significantly changed (P lt;0.01), decreased by 37.60% and 66.3% and the control group, combined treatment group effect is more pronounced (P lt;O.01). Conclusion: Pancreatic kallikrein than the combined angiotensin-converting enzyme inhibitors, angiotensin-converting enzyme inhibitors alone slow down or reverse the early diabetic kidney disease to clinical proteinuria and chronic renal failure progress. [Keywords] ACEI TPK urinary albumin To explore how to more effectively slow down and reversal of diabetic nephropathy (DN) of development, this study of 60 patients with early DN patients, clinical observations, of which 60 cases using Enalapril pancreatic kallikrein (Yee open) treatment of early DN to observe the 12 weeks through the urinary albumin (UAER), results were satisfactory, the report is as follows. 1 Materials and Methods 1.1 General Information Collected in October 2005 hospitalized patients in December 2006, according to WHO (1999) diagnostic criteria for diabetes were included 60 cases of type 2 diabetes are overweight body. Decile method with random row of the list control group of 30 patients, combined treatment group of 30 patients , two groups were age, gender, body mass index, FBG, HbALc, blood pressure, UAER and other basic match. MAIN OUTCOME MEASURES .1 weeks for the detection of urinary albumin more than 3 times (ELISA) were 30 ~ 300 mg / 24 h, between all the medical records are othe