Patients with esophageal carcinoma in peripheral blood of multiple tumor markers and its significance.docVIP

 PAGE \* MERGEFORMAT 16 Patients with esophageal carcinoma in peripheral blood of multiple tumor markers and its significance Author: DU Yan Jian-Guo Dai Ping-Ping Wu Pei-Lin Huang [Abstract] Objective To investigate the melanoma antigen (MAGEA3), human stanniocalcin (hSTC1), epithelial cells, keratin (CK20, CK19) and carcinoembryonic antigen (CEA) and other tumor markers in the peripheral blood of patients with esophageal carcinoma Expression and tumor metastasis. Methods RT-PCR to detect MAGEA3, hSTC1, CK20, CK19 and CEA mRNA in 55 esophageal cancer patients before the expression of peripheral blood and analyze the results and clinical parameters to express the relationship between. Results 55 cases of esophageal cancer in patients with peripheral venous blood MAGEA3, hSTC1, CK20, CK19 and CEA mRNA positive rates were 25.45%, 47.27%, 49.09%, 34.55% and 52.73%, while detection of the five kinds of target genes, if at least One expression can be recorded as positive expression, the positive rate of 72.73%. In addition to CK19 addition, MAGEA, hSTC1, CK20, CEA mRNA expression and tumor metastasis were associated (P amp;lt;0.05). Conclusions RT-joint detection MAGEA3, hSTC1, CK20, and CEA can increase the detection sensitivity of cancer cells in peripheral blood circulation, in order to understand the biological behavior of malignant tumor (invasion and metastasis) to provide a basis, so as to guide clinical treatment options and prognosis and the monitoring of therapeutic efficacy to help. [Keywords:] esophageal melanoma antigen-A3 human stanniocalcin an epithelial cell keratin CEA Clinical significance of detection of MAGEA3, hSTC1, CK20, CK19 and CEA mRNA in the peripheral blood from patients with esophageal carcinoma Du Yan, Dai Jianguo, Wu Pingping, et al. Department of Pathology and Pathophysiology, School of Basic Medical Science, Southeast University, Nanjing 210009. [Abstract] Objective To study the relationship between the express