Peptic ulcer disease related risk factors analysis of synergy.doc

 PAGE \* MERGEFORMAT 10 Peptic ulcer disease related risk factors analysis of synergy Abstract Objective To understand the risk factors associated peptic ulcer patients (mainly taking NSAIDs with Hp infection), synergistic pathogenic effect. Methods Case control study of 200 patients with peptic ulcer patients and 52 patients with upper gastrointestinal bleeding and 206 cases during the same period of non-treatment of gastric and duodenal disease patients taking NSAIDs and Investigation of the detection of Hp infection . Results taking NSAIDs combined risk of gastric Hp infection OR = 19.11, significantly higher than those taking NSAIDs (OR = 5.93) and Hp infection alone (OR = 5.74) risk of gastric ulcer and OR values; taking NSAIDs combined occurrence of Hp infection of upper gastrointestinal bleeding gastric ulcer OR = 3.73, upper gastrointestinal bleeding in patients with duodenal ulcer OR = 0.93, were lower than simply taking NSAIDs and Hp infection in patients with gastric ulcer (OR, 3.9 and 0.56, respectively) and duodenal ulcer patients (OR = 4.7 and 0.42, respectively) occurred on the value of gastrointestinal bleeding, and OR; with no ulcer without NSAIDs were more services, intermittent bleeding ulcer medication OR = 3.99, OR = short-term medication 2.89, OR = long-term medication were 3.39, compared three groups no significant difference (Pgt; 0.05). Elderly patients suffering from duodenal ulcer 33/120 (27.5%), compared with the non-elderly group there was a significant difference (P lt;0.01). Conclusion taking NSAIDs, and the formation of Hp infection in gastric ulcer synergy exists; in ulcer incidence of upper gastrointestinal hemorrhage there is no synergy; ulcer upper gastrointestinal bleeding and the duration of taking NSAIDs has nothing to do; age factor in second refers to the pathogenesis of ulcer play an important role. Keywords: peptic ulcer; risk factors; synergistic pathogenicity The development of peptic ulcer, smoking, dri