Pharmacological activity of PNS Progress.doc

 PAGE \* MERGEFORMAT 8 Pharmacological activity of PNS Progress Abstract] Objective To review the last 3 years PNS pharmacological activity. Methods access to the relevant literature, and analyzed and summarized. Results PNS with multiple therapeutic targets in the anti-inflammatory, antitumor, anti-interstitial fibrosis, etc. showed significant pharmacological activity, and is widely used in ischemic cardiovascular and cerebrovascular diseases. Conclusion PNS in the fight against cardiovascular disease and so worthy of further development and application. [Keywords:] Summary of pharmacological effects of PNS Panax notoginseng saponins (PNS) in Panax up to 12% in the content, containing a variety of single saponin. Modern pharmacological studies have shown that, PNS has more therapeutic targets [1], in the anti-inflammatory, antitumor, anti-interstitial fibrosis, etc. showed significant pharmacological activity, and is widely used in ischemic cardiovascular and cerebrovascular diseases. this thesis to the nearest 3 years pharmacological studies on PNS cases reviewed, designed to better study and use of the future PNS provide the basic data. 1 on ischemic brain injury 1.1 against cerebral ischemia-reperfusion injury in cerebral ischemia-reperfusion injury (CIRI) is the ischemic brain tissue after the resumption of blood perfusion, there is more obvious than before perfusion, a more serious injury and dysfunction. Tang Ying et al [2] detection of brain ischemia and reperfusion, by activating matrix metalloproteinase -9 (MMP-9), caused by extracellular matrix (ECM) damage, leading to neuronal damage, PNS can inhibit the brain after cerebral ischemia and reperfusion the expression of MMP-9 enhance matrix metalloproteinase inhibitor-l (TIMP-1) expression significantly increased brain after cerebral ischemia neuronal survival, reducing cerebral ischemic injury. 1.2 Anti-hypoxic-ischemic brain injury in hypoxic-ischemic brain injury a