Phospholipid complex baicalein Preparation and Characterization of.docVIP

 PAGE \* MERGEFORMAT 16 Phospholipid complex baicalein Preparation and Characterization of [Abstract] Objective: To study the baicalein phospholipid complex preparation process, and investigate the physical and chemical properties. Methods: baicalein with phospholipid composite rate index, by single factor experiments and orthogonal design of reaction solvent, the feed ratio, reaction temperature, reaction time and initial concentration of the compound rate of study baicalein phospholipid complex physical and chemical properties. Results: The identified phospholipid complex baicalein best preparation process: the reaction solvent is ethyl acetate, baicalein and phospholipid 1:4 feed ratio, reaction temperature is 40 , the concentration of the reactants 5 mg / ml, stirring return 2 hX-ray diffraction analysis showed that the amorphous compound showed characteristic infrared spectra indicate that the baicalein and phospholipid were no new chemical bonds formed. phospholipid complex significantly improved the baicalein in water and octanol in solubility. Conclusion: To determine the preparation of baicalein phospholipid complex the optimum, and its phospholipid complex significantly improved the original drug physical and chemical properties. [Keywords:] baicalein, phospholipid complex, physical and chemical properties [Abstract] Objective: To investigate the preparation and physic chemical properties of baicalein phospholipid.Methods: The effect of such factors as the solvent of reaction, the ratio of reactants, the reactive temperature, the reactive time and the concentration of reactants was studied by the single factor tests and orthogonal design. And the physic chemical properties of baicalein phytosome were examined.Results: The optimal conditions were obtained as follows: the ratio of baicalein to phospholipid was 1:4, the reactive time was 2 h, the reactive temperature was 40 and the concentration of reactants was 5 mg / ml. X ray diffraction spe