Pill on the new positive platelets in patients with migraine 5-HT2A receptors and adhesion molecules expression.doc

 PAGE \* MERGEFORMAT 13 Pill on the new positive platelets in patients with migraine 5-HT2A receptors and adhesion molecules expression Of: Zhu sake, Xie Wei, Chen Baotian, Xiaolie steel, to the Shi-ping [Abstract] Objective is to explore new migraine patients Pill on platelet 5-HT2A receptor mRNA and expression of adhesion molecules and their mutual relationship. Methods 68 patients were divided into 2 groups, the treatment group (35 cases) of oral New Pill is the control group (33 cases) of oral flunarizine capsules. detected by RT-PCR in patients with migraine platelet 5-HT2A receptor mRNA, detected by flow cytometry in patients with migraine CD41 in whole blood platelet membrane and CD62P. efficacy of the treatment group than the control group. Migraine 5-HT2A receptor mRNA expression in normal attack with a significant difference in Pill through the new treatment is significantly reduced its expression. Migraine attack, intermittent expression of adhesion molecules on the platelet membrane than normal artificially high, and the new working day pill can decrease its expression. Conclusion migraine 5-HT2A receptor mRNA expression and the expression of platelet adhesion molecules were significantly enhanced by the new working day pill may reduce the expression of these indicators inhibition of platelet activation, so as to achieve therapeutic purposes. [Keywords:] migraine ,5-HT2A receptors, adhesion molecules, a new positive Pill Abstract: Objective To investigate changes in the expression of 5-HT2A receptor mRNA and platelet membrane adhesion molecules in migraineurs during the periods of attack and intermittence therapy by Xinzhengtian Pill (XZTP). To study the interrelation between the expression of 5-HT2A receptor mRNA and platelet membrane adhesion molecules. Methods 68 patients were randomly divided into XZTP (therapy) group and Flunarizine (control) group. The RT-PCR method and the image pattern analysis semiquantitation method were use