Pioglitazone with lifestyle intervention on blood pressure in spontaneously hypertensive rats.doc

 PAGE \* MERGEFORMAT 12 Pioglitazone with lifestyle intervention on blood pressure in spontaneously hypertensive rats Of: Jie Chen Haiyan Wang Wei Jian Kong [Abstract] Objective To evaluate the insulin sensitizer pioglitazone (PIO) meet the lifestyle intervention in spontaneously hypertensive rats (SHR’s blood pressure. Methods 35 SHR were randomly divided into 3 groups (SHR control group, PIO and PIO treatment group with the lifestyle intervention group), drugs to rats in drinking water, investment and lifestyle interventions to reduce food intake and daily swim 6 ~ 15 min, period 12 w, using the indirect method of measuring blood pressure. outcome and with the lifestyle intervention group PIO good diet control rats, swimming capacity is gradually increased, no accidental death. PIO has a good antihypertensive effect, antihypertensive drugs with better lifestyle intervention, weight control. Conclusion PIO and with a good lifestyle intervention reduced SHR Effects of blood pressure, lifestyle intervention can be used to correct insulin resistance (IR) one of the methods were applied to the treatment of hypertension. [Keywords:] insulin sensitizer; insulin resistance; lifestyle; hypertension [Abstract] Objective To evaluate the effects of insulin sensilizer (Pioglitazone PIO) combining with life style intervention on blood pressure in spontaneously hypertensive rats (SHRs). Methods 35 SHRs were randomly divided into SHR control, PIO (PIO 45 mg / L in drinking water) and PIO combining with life style intervention groups. Decreasing the rat food and swimming 6 ~ 15 min / d acted as life style intervention. Results Rats in PIO combining with life style intervention group had well alimentary control and swimming ability, without accidental death . PIO had satisfactory effects on depressurization. PIO combining with life style intervention had better lowering blood pressure effect and better weight control effect. Conclusions PIO combining with life styl