Plasma substitutes classification and clinical application of comparative.doc

 PAGE \* MERGEFORMAT 4 Plasma substitutes classification and clinical application of comparative Author: Zhou Zhongying Huzhong Jie Zhi-Hong Xu [Keywords:] plasma Of plasma and plasma substitutes used in a large number of blood loss, loss of plasma and large-scale burns caused by reduced blood volume, shock and other emergencies, for the expansion of blood volume, improve microcirculation and in improving the survival rate of patients plays a very an important role. The ideal plasma substitutes have a stable physical and chemical properties, can be quickly added that blood volume, increase tissue perfusion and blood vessels have sufficient residence time, while on blood coagulation and renal function had no significant effect, no allergic reaction and organization of toxicity, can improve the oxygen supply and organ function and metabolism in the body and remove easily. In recent years, the shortage of blood, the global plasma substitutes on the end of the study Franshion Ai, one after another, some of hydroxyethyl starch molecules have been successfully developed into clinical use. With the development of science and clinical application of plasma substitutes in a wide range of clinical staff in a more comprehensive understanding of the various alternatives need physical and chemical properties and function, safety and other aspects of knowledge. Therefore, this article on various artificial plasma substitutes have been studied summarized information for clinical application. A classification of artificial colloid plasma substitutes 1.1 Dextran According to aggregate the different number of glucose molecules can be divided into medium-molecular weight dextran (eg, D -70, molecular weight 70kDa); low molecular weight dextran (eg dextran -40); smaller molecular weight dextran ( such as the spin sugar under -10). Dextran can increase plasma colloid osmotic pressure to absorb extravascular water to supplement the blood volume and thus maintain blood pressu