Polygonum butanol extract on cerebral ischemia-reperfusion injury in rats.docVIP

 PAGE \* MERGEFORMAT 10 Polygonum butanol extract on cerebral ischemia-reperfusion injury in rats Of: Liliang Dong, Zhi-Hua Huang, Yuxing Mei, Li Xiao, Jing has been [Abstract] Objective Polygonum butanol extract on cerebral ischemia-reperfusion injury, and to investigate its protective mechanism. Methods middle cerebral artery occlusion, the production model of cerebral ischemia and reperfusion injury, ischemia 10 min, at different doses of sublingual intravenous n-butanol extract of Polygonum. reperfusion 24 h, brains were removed, TTC staining, infarct volume determination; blood after centrifugation, in serum, colorimetry Measurement of serum NOS, SOD activity and NO, MDA levels. Results Compared with model group, n-butanol extract of Polygonum infarct volume was reduced in treatment group, serum SOD activity and increased NOS, NO content was increased, MDA content was decreased. Conclusion Polygonum butanol extract on cerebral ischemia-reperfusion injury has a protective role in the protective mechanism and butanol extract Polygonum promote NO release and increased oxygen free radical scavenging related. [Keywords:] Polygonum butanol extract; cerebral ischemia-reperfusion injury Abstract: ObjectiveTo explore the therapeutic effects of n-Butyl alcohol extract of Polygonum bistorla L. on cerebral ischemia / reperfusion injury and its mechanism. MethodsA rat cerebral ischemia / reperfusion injury was made through embolization of the middle cerebral artery, and the injury was treated with n-Butyl alcohol extract of Polygonum bistorla L., using sublingual vein injection. The cerebral tissue was stained using the TTC method, and the infarction volume was investigated. Moreover, the activities of NOS and SOD, and the levels of NO and MDA were also measured. ResultsAfter treatment, a reduction in the infarction volume and elevation in the activities of NOS and SOD in serum were observed. An elevation in NO level and a decrease in MDA level were also ob